DN2M » Technology » Methodological plateform » Clinical Imaging

Clinical Imaging

Our goal is to develop quantitative MRI techniques in order to detect anatomical or functional changes in the brain related to neuro-degenerative diseases. The neuro-imaging lab is currently involved in a number of clinical research protocols with close relationship between radiologists, neurologists and engineers. We are also developing advanced MR sequences and data processing tools in techniques such as :

Diffusion Tensor Imaging (DTI) : Visualization of white matter fibers (“cables” that link neurons together). Example of application : Brain connectivity assessment.

Example of Track Density Imaging (from supersampled DTI)
Sub-selection of fibers

Functional MRI (fMRI) : Resting state, block or event-related paradigm. Example of application : functional connectivity of the brain.

Default mode network

Arterial Spin Labeling (ASL) : Non-invasive Cerebral Blood Flow (CBF) measurement.

Example of graph connectivity

Structural MRI

CBF cartography

Example of cortical thickness measurment (mm)

Example of cortical complexity mapping

Resources :

  • 3T Philips MRI and dedicated coils
  • functional MRI devices (non-magnetic flat screen, responses pad, Psychtoolbox and Cogent 2000, …)
  • Image archiving and processing platform running under Linux.
  • High performance computer cluster : 13 nodes (~90 slots) for fast and heavy data processing.